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Metabolism: Oxycodone hydrochloride is extensively metabolized to noroxycodone, oxymorphone, and their glucuronides. The major circulating metabolite is noroxycodone with an AUC ratio of 0.The concomitant usage of OXYCONTIN and CYP3A4 inhibitors can enhance the plasma concentration of oxycodone, causing elevated or prolonged opioid results.Actual p